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Read more about Tirzepatide below or click the DOCX button to download

Medication Guide TIRZEPATIDE 

(tirzepatide)
injection, for subcutaneous use 

What is the most important information I should know about TIRZEPATIDE? 

TIRZEPATIDE may cause serious side effects, including: 

  • Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rats, TIRZEPATIDE and medicines that work like TIRZEPATIDE caused thyroid tumors, including thyroid cancer. It is not known if TIRZEPATIDE will cause thyroid tumors, or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people. 

  • Do not use TIRZEPATIDE if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC), or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). 

What is TIRZEPATIDE? 

  • TIRZEPATIDE is an injectable prescription medicine that is used along with diet and exercise to improve blood sugar (glucose) in adults with type 2 diabetes mellitus. 

  • It is not known if TIRZEPATIDE can be used in people who have had pancreatitis. 

  • TIRZEPATIDE is not for use in people with type 1 diabetes. 

  • It is not known if TIRZEPATIDE is safe and effective for use in children under 18 years of age. 

Do not use TIRZEPATIDE if: 

  • you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC) or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). 

  • you have had a serious allergic reaction to tirzepatide or any of the ingredients in TIRZEPATIDE. See the end of this Medication Guide for a complete list of ingredients in TIRZEPATIDE. 

Before using TIRZEPATIDE, tell your healthcare provider about all of your medical conditions, including if you: 

  • have or have had problems with your pancreas or kidneys. 

  • have severe problems with your stomach, such as slowed emptying of your stomach (gastroparesis) or problems 

with digesting food. 

  • have a history of diabetic retinopathy. 

  • are pregnant or plan to become pregnant. It is not known if TIRZEPATIDE will harm your unborn baby. Tell your healthcare provider if you become pregnant while using TIRZEPATIDE. 

○ Birth control pills by mouth may not work as well while using TIRZEPATIDE. If you take birth control pills by mouth, your healthcare provider may recommend another type of birth control for 4 weeks after you start TIRZEPATIDE and for 4 weeks after each increase in your dose of TIRZEPATIDE. Talk to your healthcare provider about birth control methods that may be right for you while using TIRZEPATIDE. 

• are breastfeeding or plan to breastfeed. It is not known if TIRZEPATIDE passes into your breast milk. Talk to your healthcare provider about the best way to feed your baby while using TIRZEPATIDE. 

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TIRZEPATIDE may affect the way some medicines work, and some medicines may affect the way TIRZEPATIDE works.

Before using TIRZEPATIDE, tell your healthcare provider if you are taking other medicines to treat diabetes including insulin or sulfonylureas which could increase your risk of low blood sugar. Talk to your healthcare provider about low blood sugar and how to manage it. 

How should I use TIRZEPATIDE? 

  • Read the Instructions for Use that comes with TIRZEPATIDE. 

  • Use TIRZEPATIDE exactly as your healthcare provider tells you to. 

  • TIRZEPATIDE is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. 

  • Use TIRZEPATIDE 1 time each week, at any time of the day. 

  • You may change the day of the week you use TIRZEPATIDE as long as the time between the 2 doses is at least 3 days (72 hours). 

  • If you miss a dose of TIRZEPATIDE, take the missed dose as soon as possible within 4 days (96 hours) after the missed dose. If more than 4 days have passed, skip the missed dose and take your next dose on the regularly scheduled day. Do not take 2 doses of TIRZEPATIDE within 3 days of each other. 

  • TIRZEPATIDE may be taken with or without food. 

  • Do not mix insulin and TIRZEPATIDE together in the same injection. 

  • You may give an injection of TIRZEPATIDE and insulin in the same body area (such as your stomach area), but not right next to each other. 

  • Change (rotate) your injection site with each weekly injection. Do not use the same site for each injection. 

  • If you take too much TIRZEPATIDE, call your healthcare provider. 

What are the possible side effects of TIRZEPATIDE? TIRZEPATIDE may cause serious side effects, including: 

  • See “What is the most important information I should know about TIRZEPATIDE?” 

  • inflammation of your pancreas (pancreatitis). Stop using TIRZEPATIDE and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without vomiting. You may feel the pain from your abdomen to your back. 

  • low blood sugar (hypoglycemia). Your risk for getting low blood sugar may be higher if you use TIRZEPATIDE with another medicine that can cause low blood sugar, such as a sulfonylurea or insulin. Signs and symptoms of low blood sugar may include: 

  • ○  dizziness or light-headedness 

  • ○  sweating 

  • ○  confusion or drowsiness 

  • ○  headache 

○ blurred vision ○ slurred speech ○ shakiness
○ fast heartbeat 

○ anxiety, irritability, or mood changes ○ hunger
○ weakness
○ feeling jittery 

  • serious allergic reactions. Stop using TIRZEPATIDE and get medical help right away if you have any symptoms of a serious allergic reaction including: 

    • ○  swelling of your face, lips, tongue or throat ○ fainting or feeling dizzy 

    • ○  problems breathing or swallowing ○ very rapid heartbeat 

    • ○  severe rash or itching 

  • kidney problems (kidney failure). In people who have kidney problems, diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems to get worse. It is important for you to drink fluids to help reduce your chance of dehydration. 

  • severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use TIRZEPATIDE. Tell your healthcare provider if you have stomach problems that are severe or will not go away. 

  • changes in vision. Tell your healthcare provider if you have changes in vision during treatment with TIRZEPATIDE. 

  • gallbladder problems. Gallbladder problems have happened in some people who use TIRZEPATIDE. Tell your 

healthcare provider right away if you get symptoms of gallbladder problems which may include: 

  • ○  pain in your upper stomach (abdomen) ○ yellowing of skin or eyes (jaundice) 

  • ○  fever ○ clay-colored stools 

Reference ID: 4983783 

The most common side effects of TIRZEPATIDE include: 

• nausea
• diarrhea
• decreased appetite • vomiting 

• constipation
• indigestion
• stomach (abdominal) pain 

Talk to your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of TIRZEPATIDE. Call your doctor for medical advice about side effects. 

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